We retrieved 6238 records 48 (51 cases) met the inclusion criteria. Reports on chronic poisoning, studies describing adverse effects of therapeutic use, and animal studies were excluded. At least one serum lamotrigine concentration had to be reported for inclusion. Articles were eligible if they described acute or acute on chronic lamotrigine overdose. Major bibliographic databases were updated on. We performed a literature search across eight databases, including Medline, EMBASE, and the Cochrane Library, from database inception to April 2014. To characterize manifestations of acute lamotrigine overdose, determine if serum concentrations predict poisoning severity, and evaluate the effectiveness of overdose management interventions. We undertook a systematic review of the literature on lamotrigine overdoses to better understand the clinical severity, the relevance of serum concentrations, and therapeutic interventions for overdose. However, there are reported cases of cardiac arrest and mortality following lamotrigine overdose. Evidence from case series and retrospective studies indicate that lamotrigine overdose is usually benign. Lamotrigine is a broad-spectrum anticonvulsant commonly used to treat seizure and bipolar mood disorders.
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